DPP-4 inhibitors

Here We Go Again: Another New Therapy For Type 2 Diabetes

(Full disclosure – I am an Advisor to Janssen pharmaceuticals that makes canagliflozin) 
An FDA advisory panel last week reviewed canagliflozin, with the majority recommending approval. Canaglifozin is the first member of a new class of oral medications for type 2 diabetes–sodium-glucose co-transportor-2 (SGLT2) inhibitors–that will likely make it to the U.S. market.

Who is the Right Patient for SGLT-2 Inhibitors?

Dr. Leahy’s comments are right-on target. Some further observations by another endocrinologist who can’t determine who the best patient for this new class of drugs will be:
1.     The advisory committee had problems with the bump in LDL-cholesterol. True, this is a surrogate, not a true “outcome” that will be determined in the CANVAS study. But do you recall the last time we had this debate with a diabetes drug?