Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets.

DeVries, J Hans; Bain, Stephen C; Rodbard, Helena W; Seufert, Jochen; D'Alessio, David; Thomsen, Anne B; Zychma, Marcin; Rosenstock, Julio
Diabetes care; 2012 Jul;35(7):1446-54. PMID: 22584132
Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands.


We evaluated the addition of liraglutide to metformin in type 2 diabetes followed by intensification with basal insulin (detemir) if glycated hemoglobin (A1C) ≥7%.