Simultaneous glyburide/metformin therapy is superior to component monotherapy as an initial pharmacological treatment for type 2 diabetes.

Garber, A J; Larsen, J; Schneider, S H; Piper, B A; Henry, D
Diabetes, obesity & metabolism; 2002 May;4(3):201-8. PMID: 12047399
Baylor College of Medicine and The Methodist Hospital, Houston, Texas 77030, USA.


To evaluate whether simultaneous initial treatment of both insulin resistance and impaired beta-cell insulin secretion with glyburide/metformin tablets is superior to monotherapy with each component agent.