Are statins diabetogenic?

Sampson, Uchechukwu K; Linton, Macrae F; Fazio, Sergio
Current opinion in cardiology; 2011 Jul;26(4):342-7. PMID: 21499090
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6300, USA.


Statins are widely utilized for low-density lipoprotein lowering and for prevention of atherosclerotic cardiovascular disease. Although these drugs have a good safety record, increased risk of developing diabetes during extended use has recently garnered attention. Here we review clinical trial evidence related to statin use and incident diabetes, and the potential mechanisms for this association.