The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease.

Belch, Jill; MacCuish, Angus; Campbell, Iain; Cobbe, Stuart; Taylor, Roy; Prescott, Robin; Lee, Robert; Bancroft, Jean; MacEwan, Shirley; Shepherd, James; Macfarlane, Peter; Morris, Andrew; Jung, Roland; Kelly, Christopher; Connacher, Alan; Peden, Norman;
BMJ (Clinical research ed.); 2008;337:a1840. PMID: 18927173
Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee DD1 9SY.


To determine whether aspirin and antioxidant therapy, combined or alone, are more effective than placebo in reducing the development of cardiovascular events in patients with diabetes mellitus and asymptomatic peripheral arterial disease.