Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial.

Hovorka, Roman; Allen, Janet M; Elleri, Daniela; Chassin, Ludovic J; Harris, Julie; Xing, Dongyuan; Kollman, Craig; Hovorka, Tomas; Larsen, Anne Mette F; Nodale, Marianna; De Palma, Alessandra; Wilinska, Malgorzata E; Acerini, Carlo L; Dunger, David B
Lancet; 2010 Feb 27;375(9716):743-51. PMID: 20138357
Department of Paediatrics, University of Cambridge, Cambridge, UK.


Closed-loop systems link continuous glucose measurements to insulin delivery. We aimed to establish whether closed-loop insulin delivery could control overnight blood glucose in young people.