Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis.

Loke, Yoon K; Singh, Sonal; Furberg, Curt D
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne; 2009 Jan 6;180(1):32-9. PMID: 19073651
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK.


Rosiglitazone and pioglitazone may increase the incidence of fractures. We aimed to determine systematically the risk of fractures associated with thiazolidinedione therapy and to evaluate the effect of the therapy on bone density.