Long-term use of thiazolidinediones and the associated risk of pneumonia or lower respiratory tract infection: systematic review and meta-analysis.

Singh, Sonal; Loke, Yoon K; Furberg, Curt D
Thorax; 2011 May;66(5):383-8. PMID: 21325145
Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St, Suite 8063, Baltimore, MD 21287, USA.


The peroxisome proliferator-activated receptor-γ agonists rosiglitazone and pioglitazone activate glucocorticoid receptors and have an immunomodulatory effect. The authors aimed to systematically determine the risk of pneumonia or lower respiratory tract infections associated with thiazolidinediones.