Larsen, Claus M; Faulenbach, Mirjam; Vaag, Allan; Vølund, Aage; Ehses, Jan A; Seifert, Burkhardt; Mandrup-Poulsen, Thomas; Donath, Marc Y
The New England journal of medicine; 2007 Apr 12;356(15):1517-26. PMID: 17429083
Steno Diabetes Center, Gentofte, Denmark.
Abstract
The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading to impaired insulin secretion, decreased cell proliferation, and apoptosis.