High-dose insulin therapy: is it time for U-500 insulin?

Lane, Wendy S; Cochran, Elaine K; Jackson, Jeffrey A; Scism-Bacon, Jamie L; Corey, Ilene B; Hirsch, Irl B; Skyler, Jay S
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists; 15(1):71-9. PMID: 19211405


To provide an overview of U-500 regular insulin action, review published clinical studies with U-500 regular insulin, and offer guidance to practicing endocrinologists for identifying patients for whom U-500 regular insulin may be appropriate.