Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group.

Hansson, L; Zanchetti, A; Carruthers, S G; Dahlöf, B; Elmfeldt, D; Julius, S; Ménard, J; Rahn, K H; Wedel, H; Westerling, S
Lancet; 1998 Jun 13;351(9118):1755-62. PMID: 9635947


Despite treatment, there is often a higher incidence of cardiovascular complications in patients with hypertension than in normotensive individuals. Inadequate reduction of their blood pressure is a likely cause, but the optimum target blood pressure is not known. The impact of acetylsalicylic acid (aspirin) has never been investigated in patients with hypertension. We aimed to assess the optimum target diastolic blood pressure and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension.