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A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir.

Plank, Johannes; Bodenlenz, Manfred; Sinner, Frank; Magnes, Christoph; Görzer, Evelyn; Regittnig, Werner; Endahl, Lars A; Draeger, Eberhard; Zdravkovic, Milan; Pieber, Thomas R
Diabetes care; 2005 May;28(5):1107-12. PMID: 15855574
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Abstract

To investigate the pharmacodynamic profile and duration of action for five subcutaneous doses of insulin detemir (0.1, 0.2, 0.4, 0.8, and 1.6 units/kg; 1 unit = 24 nmol) and one subcutaneous dose of NPH insulin (0.3 IU/kg; 1 IU = 6 nmol).