Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice.

Tschen, Shuen-Ing; Dhawan, Sangeeta; Gurlo, Tatyana; Bhushan, Anil
Diabetes; 2009 Jun;58(6):1312-20. PMID: 19228811
Larry L. Hillblom Islet Research Center, Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA.


The aim of this study was to elucidate whether age plays a role in the expansion or regeneration of beta-cell mass.