Adaptive beta-cell proliferation is severely restricted with advanced age.

Rankin, Matthew M; Kushner, Jake A
Diabetes; 2009 Jun;58(6):1365-72. PMID: 19265026
Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.


Regeneration of the insulin-secreting beta-cells is a fundamental research goal that could benefit patients with either type 1 or type 2 diabetes. beta-Cell proliferation can be acutely stimulated by a variety of stimuli in young rodents. However, it is unknown whether this adaptive beta-cell regeneration capacity is retained into old age.