Holman, Rury R; Paul, Sanjoy K; Bethel, M Angelyn; Matthews, David R; Neil, H Andrew W
The New England journal of medicine; 2008 Oct 9;359(15):1577-89. PMID: 18784090
Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom. rury.holman@dtu.ox.ac.uk
Abstract
During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes mellitus who received intensive glucose therapy had a lower risk of microvascular complications than did those receiving conventional dietary therapy. We conducted post-trial monitoring to determine whether this improved glucose control persisted and whether such therapy had a long-term effect on macrovascular outcomes.