Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Shu, Luan; Matveyenko, Aleksey V; Kerr-Conte, Julie; Cho, Jae-Hyoung; McIntosh, Christopher H S; Maedler, KathrinHuman molecular genetics; 2009 Jul 1;18(13):2388-99. PMID: 19386626Category: PathophysiologyTags: beta cell pathophysiology
Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Tschen, Shuen-Ing; Dhawan, Sangeeta; Gurlo, Tatyana; Bhushan, AnilDiabetes; 2009 Jun;58(6):1312-20. PMID: 19228811Category: PathophysiologyTags: beta cell pathophysiology
Adaptive beta-cell proliferation is severely restricted with advanced age. Rankin, Matthew M; Kushner, Jake ADiabetes; 2009 Jun;58(6):1365-72. PMID: 19265026Category: PathophysiologyTags: beta cell pathophysiology
Functional pancreatic beta-cell mass: involvement in type 2 diabetes and therapeutic intervention. Karaca, M; Magnan, C; Kargar, CDiabetes & metabolism; 2009 Apr;35(2):77-84. PMID: 19251449Category: Pathophysiology
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. da Silva Xavier, Gabriela; Loder, Merewyn K; McDonald, Angela; Tarasov, Andrei I; Carzaniga, Raffaella; Kronenberger, Katrin; Barg, Sebastian; Rutter, Guy ADiabetes; 2009 Apr;58(4):894-905. PMID: 19168596Category: PathophysiologyTags: beta cell pathophysiology
Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Tabara, Yasuharu; Osawa, Haruhiko; Kawamoto, Ryuichi; Onuma, Hiroshi; Shimizu, Ikki; Miki, Tetsuro; Kohara, Katsuhiko; Makino, HideichiDiabetes; 2009 Feb;58(2):493-8. PMID: 19033397Category: Pathophysiology
Beyond Insulin Resistance: Islet Cells as Key Drivers in Type 2 DM Leahy, Jack L.Translational Working Group on Beta Cell and Islet Cell DysfunctionCategory: Pathophysiology
Issues of Beta Cell Dysfunction Weir, Gordon C.Translational Working Group on Beta Cell and Islet Cell DysfunctionCategory: Pathophysiology
The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance. Abdul-Ghani, Muhammad A; Matsuda, Masafumi; Jani, Rucha; Jenkinson, Christopher P; Coletta, Dawn K; Kaku, Kohei; DeFronzo, Ralph AAmerican journal of physiology. Endocrinology and metabolism; 2008 Aug;295(2):E401-6. PMID: 18492770Category: Pathophysiology
Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test. Festa, Andreas; Williams, Ken; Hanley, Anthony J G; Haffner, Steven MDiabetes; 2008 Jun;57(6):1638-44. PMID: 18332099Category: Pathophysiology