thiazolidinediones (TZDs)

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Case 5: Graduate Student with Atypical Symptoms

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A 25-year-old graduate student originally presented to you with symptoms of a UTI. An urinanalysis showed signs of infection, as well as glycosuria.

Tailoring Clinical Practice Guidelines for Patients with Type 2 Diabetes

Posted September 21, 2011 by Sonal Singh, MD, MPH
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Several guidelines emphasize the need to use existing therapeutic options to help patients and providers achieve various treatment goals, including target glycated hemoglobin levels to improve microvascular outcomes among patients with type 2 diabetes.

Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis.

Loke, Yoon K; Singh, Sonal; Furberg, Curt D
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne; 2009 Jan 6;180(1):32-9. PMID: 19073651;
Category: Interventions / Thiazolidinediones - TZDs;
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Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies.

Loke, Yoon Kong; Kwok, Chun Shing; Singh, Sonal
BMJ (Clinical research ed.); 2011;342:d1309. PMID: 21415101;
Category: Interventions / Thiazolidinediones - TZDs;
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Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations.

Bennett, Wendy L; Maruthur, Nisa M; Singh, Sonal; Segal, Jodi B; Wilson, Lisa M; Chatterjee, Ranee; Marinopoulos, Spyridon S; Puhan, Milo A; Ranasinghe, Padmini; Block, Lauren; Nicholson, Wanda K; Hutfless, Susan; Bass, Eric B; Bolen, Shari
Annals of internal medicine; 2011 May 3;154(9):602-13. PMID: 21403054;
Category: Interventions;
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Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT.

Kahn, Steven E; Lachin, John M; Zinman, Bernard; Haffner, Steven M; Aftring, R Paul; Paul, Gitanjali; Kravitz, Barbara G; Herman, William H; Viberti, Giancarlo; Holman, Rury R
Diabetes; 2011 May;60(5):1552-60. PMID: 21415383;
Category: Interventions / Thiazolidinediones - TZDs;
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Pioglitazone for diabetes prevention in impaired glucose tolerance.

DeFronzo, Ralph A; Tripathy, Devjit; Schwenke, Dawn C; Banerji, MaryAnn; Bray, George A; Buchanan, Thomas A; Clement, Stephen C; Henry, Robert R; Hodis, Howard N; Kitabchi, Abbas E; Mack, Wendy J; Mudaliar, Sunder; Ratner, Robert E; Williams, Ken; Stentz, Frankie B; Musi, Nicolas; Reaven, Peter D
The New England journal of medicine; 2011 Mar 24;364(12):1104-15. PMID: 21428766;
Category: Interventions / Thiazolidinediones - TZDs;
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Can Current Drug Therapy Prevent Beta Cell Failure and Bring Treatment Durability in T2DM?

Posted July 20, 2011 by John L. Leahy, MD
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A hot topic in the type 2 diabetes world is whether we have in hand the tools to stop the decline in beta cell function that typifies this disease and, consequently, a therapy or therapies that successfully control blood glucose for many years – so-called treatment durability.

T2DM and Fatty Liver Disease: Is What’s Good for the Gander Good for the Goose?

Posted April 7, 2011 by Kim C. Dixon, MD
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Fatty liver disease is the most common cause of chronic liver disease in North America[1] and is becoming one of the top reasons for liver transplantation. Fatty liver causes inflammation that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma.

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