insulin therapy

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Topics include original Beta Cells in Diabetes content, as well as expert-selected resources chosen by our Editorial Board.

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Lipid-induced insulin resistance: unravelling the mechanism.

Samuel, Varman T; Petersen, Kitt Falk; Shulman, Gerald I
Lancet; 2010 Jun 26;375(9733):2267-77. PMID: 20609972;
Category: General Reviews;
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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

Morino, Katsutaro; Petersen, Kitt Falk; Dufour, Sylvie; Befroy, Douglas; Frattini, Jared; Shatzkes, Nadine; Neschen, Susanne; White, Morris F; Bilz, Stefan; Sono, Saki; Pypaert, Marc; Shulman, Gerald I
The Journal of clinical investigation; 2005 Dec;115(12):3587-93. PMID: 16284649;
Category: General Reviews;
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Case 5: Graduate Student with Atypical Symptoms

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A 25-year-old graduate student originally presented to you with symptoms of a UTI. An urinanalysis showed signs of infection, as well as glycosuria.

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes.

Currie, C J; Poole, C D; Gale, E A M
Diabetologia; 2009 Sep;52(9):1766-77. PMID: 19572116;
Category: Interventions;
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Insulin glargine use and short-term incidence of malignancies-a population-based follow-up study in Sweden.

Jonasson, J M; Ljung, R; Talbäck, M; Haglund, B; Gudbjörnsdòttir, S; Steineck, G
Diabetologia; 2009 Sep;52(9):1745-54. PMID: 19588120;
Category: Interventions;
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Combined randomised controlled trial experience of malignancies in studies using insulin glargine.

Home, P D; Lagarenne, P
Diabetologia; 2009 Dec;52(12):2499-506. PMID: 19756478;
Category: Interventions;
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Manual closed-loop insulin delivery in children and adolescents with type 1 diabetes: a phase 2 randomised crossover trial.

Hovorka, Roman; Allen, Janet M; Elleri, Daniela; Chassin, Ludovic J; Harris, Julie; Xing, Dongyuan; Kollman, Craig; Hovorka, Tomas; Larsen, Anne Mette F; Nodale, Marianna; De Palma, Alessandra; Wilinska, Malgorzata E; Acerini, Carlo L; Dunger, David B
Lancet; 2010 Feb 27;375(9716):743-51. PMID: 20138357;
Category: Interventions / Insulin;
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Prevention of nocturnal hypoglycemia using predictive alarm algorithms and insulin pump suspension.

Buckingham, Bruce; Chase, H Peter; Dassau, Eyal; Cobry, Erin; Clinton, Paula; Gage, Victoria; Caswell, Kimberly; Wilkinson, John; Cameron, Fraser; Lee, Hyunjin; Bequette, B Wayne; Doyle, Francis J
Diabetes care; 2010 May;33(5):1013-7. PMID: 20200307;
Category: Interventions / Insulin;
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Can We 'Close the Loop' With an Artificial Pancreas?

Posted August 24, 2011 by Aaron Kowalski, PhD
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For many years now, the concept of an artificial pancreas – a machine that could replace the functions of the pancreas lost due to diabetes – has been appealing and sought after.

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